Journal
TRENDS IN BIOTECHNOLOGY
Volume 35, Issue 9, Pages 871-882Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2017.04.009
Keywords
-
Categories
Funding
- Max Planck Society
- European Research Council (ERC) under the European Commission Horizon 2020 research and innovation programme (ERC-ADG) [669982]
- National Natural Science Foundation of China [31572071]
- National Key Research and Development Program of China [SQ2017YFNC030122]
- Science and Technology Department of Hubei Province of China [2016CFA052]
- Recruitment Program of Global Experts (China)
Ask authors/readers for more resources
Plant-mediated RNA interference (RNAi) shows great potential in crop protection. It relies on plants stably expressing double-stranded RNAs (dsRNAs) that target essential genes in pest insects. Practical application of this strategy is challenging because producing sufficient amounts of stable dsRNA in plants has proven to be difficult to achieve with conventional transgenesis. In addition, many insects do not respond to exogenously applied dsRNAs, either degrading them or failing to import them into the cytoplasm. We summarize recent progress in RNAi-mediated insect pest control and discuss factors determining its efficacy. Expressing dsRNA in chloroplasts overcomes many of the difficulties previously encountered. We also highlight remaining challenges and discuss the environmental and biosafety issues involved in the use of this technology in agriculture.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available