Journal
TRENDS IN BIOTECHNOLOGY
Volume 35, Issue 10, Pages 997-1013Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2017.06.012
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Funding
- City University of Hong Kong [9610363, 7200520]
- Croucher Foundation [9500030]
- UK Medical Research Council [MR/L008823/1, MR/P010873/1]
- MRC [MR/L008823/1, MR/K000535/1, MR/P010873/1] Funding Source: UKRI
- Medical Research Council [MR/L008823/1, MR/K000535/1, MR/P010873/1] Funding Source: researchfish
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Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention for decades. Recent methodological advances have advanced the identification and characterization of G-quadruplexes in vivo as well as in vitro, and at a much higher resolution and throughput, which has greatly expanded our current understanding of G-quadruplex structure and function. Accumulating knowledge about the structural properties of G-quadruplexes has helped to design and develop a repertoire of molecular and chemical tools for biological applications. This review highlights how these exciting methods and findings have opened new doors to investigate the potential functions and applications of G-quadruplexes in basic and applied biosciences.
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