Journal
TRENDS IN BIOTECHNOLOGY
Volume 35, Issue 8, Pages 770-784Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2017.05.005
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Funding
- Direction Generale de l'Armement (DGA)
- ANR ASTRID [ANR-14-ASTR-0030]
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Reconstructing functional skin after a wound remains a challenge due to the complexity of healing. In this regard, biocompatible nanoparticles (NPs) carrying and releasing bioactive drugs in a controlled and sustained manner may significantly improve the efficacy of wound therapies compared with current treatments. Topical administration of drug-loaded NPs allows optimal delivery to the dermis and improves product efficacy. Furthermore, associating NPs with scaffolds represents a new concept of 'dressing'. Experimental in vivo, ex vivo, and in vitro models have been developed in preclinical assays to evaluate the beneficial effects of nanoparticulate dressings. Drug-loaded NPs are promising tools for innovative wound healing treatment, especially with regard to their multifunctional properties.
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