Journal
TRENDS IN BIOTECHNOLOGY
Volume 35, Issue 11, Pages 1025-1034Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2017.07.006
Keywords
-
Categories
Funding
- National Science Foundation CMMI Award [1624515]
- Diabetes in Action Research and Education Foundation [426]
- Pennsylvania Department of Health (CURE) Program
- American Association of Plastic Surgeons
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1624515] Funding Source: National Science Foundation
Ask authors/readers for more resources
Type 1 diabetes mellitus is a chronic autoimmune disease that results from the destruction of beta (beta) cells in the pancreatic islets, leading to loss of insulin production and resultant hyperglycemia. Recent developments in stem cell biology have generated much excitement for beta-cell replacement strategies; beta cells are one of many cell types in the complex islet environment and pancreas. In this Opinion, we discuss recent successful attempts to generate beta cells and how this can be coupled with bioprinting technologies in order to fabricate pancreas tissues, which holds great potential for type 1 diabetes. Possibilities of integrating vascularization and encapsulation in bioprinted tissues are expounded, and future prospects, such as pancreas-on-a-chip, are also presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available