Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 42, Issue 7, Pages 516-530Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2017.05.001
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Funding
- MRC [MR/J006580/1]
- BBSRC [BB/P003818/1]
- CNRS
- Marie Curie Grant [6319977]
- BBSRC [BB/M011801/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/P003818/1, BB/M011801/1] Funding Source: researchfish
- Medical Research Council [1215854] Funding Source: researchfish
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Transfer of lipid across the cytoplasm is an essential process for intracellular lipid traffic. Lipid transfer proteins (LTPs) are defined by highly controlled in vitro experiments. The functional relevance of these is supported by evidence for the same reactions inside cells. Major advances in the LTP field have come from structural bioinformatics identifying new LTPs, and from the development of countercurrent models for LTPs. However, the ultimate aim is to unite in vitro and in vivo data, and this is where much progress remains to be made. Even where in vitro and in vivo experiments align, rates of transfer tend not to match. Here we set out some of the advances that might test how LTPs work.
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