Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 48, Pages 41648-41658Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b10608
Keywords
theranostic agent; pH-responsive; T-1/T-2 dual-mode MRI; chemotherapy; photothermal therapy; synergetic effect
Funding
- National Natural Science Foundation of China [51502284, 81571737, 21635007]
- Graduate Innovation Fund of Jilin University [2016018]
- Program of Science and Technology Development Plan of Jilin Province of China [20180101119JC, 20150520007JH, 20170101186JC]
- Youth Training Foundation by the Health and Family Planning Commission of Jilin Province [2017Q012]
Ask authors/readers for more resources
Construction of stimuli-responsive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer. Herein, we constructed a novel theranostic agent with Co-P nano composites as core, mesoporous silica as shell, and manganese dioxide (MnO2) nanosheets as gatekeeper, which have been employed for pH-activatable T-1/T-2 dual-modality magnetic resonance imaging (MRI)-guided chemotherapeutical and photo thermal combination anticancer therapy in vitro and in vivo. Co-P core-enabled theranostic platform could be applied for both photothermal therapy and T2-weighted MRI in the normal circulation owing to its strong near-infrared absorbance and intrinsic magnetic properties. In the acidic environment of tumors, MnO2 cap could be dissolved into Mn2+ ions to not only realize pH-responsive on-demand drug release but also activate Tr weighted MM contrast enhancement. Such T-1/T-2 dual-mode MR imaging provides further comprehensive details and accurate information for tumor diagnosis, and the on-demand chemo-photothermal synergetic therapy greatly improved the therapeutic effectiveness and effectively mitigated side effects. These findings demonstrate that Co-P@mSiO(2)@DOX-MnO2 are promising as pH-responsive theranostic agents for tumor diagnosis and treatment, and stimulate interest in exploration of novel stimuli responsive theranostic nanoagents which posssess good potential for clinical application in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available