Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 42, Issue 1, Pages 72-84Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.10.003
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Funding
- National Institutes of Health [AI-094141, AI-126001]
- Oklahoma Center for Advancement in Science and Technology [HR14-109]
- Presbyterian Health Foundation
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Development of the adaptive immune system is dependent on V(D)J recombination, which forms functional antigen receptor genes through rearrangement of component gene segments. The V(D)J recombinase, comprising recombination-activating proteins RAG1 and RAG2, guides the initial DNA cleavage events to the recombination signal sequence (RSS), which flanks each gene segment. Although the enzymatic steps for RAG-mediated endonucleolytic activity were established over two decades ago, only recently have high-resolution structural studies of the catalytically active core regions of the RAG proteins shed light on conformational requirements for the reaction. While outstanding questions remain, we have a clearer picture of how RAG proteins function in generating the diverse repertoires of antigen receptors, the underlying foundation of the adaptive immune system.
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