Journal
TRANSLATIONAL RESEARCH
Volume 187, Issue -, Pages 1-10Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trsl.2017.04.004
Keywords
-
Categories
Funding
- Mesothelioma Applied Research Foundation [GC229060]
- National Institutes of Health [P30 CA00874, R21 CA164568-01A1]
- U.S. Department of Defense [PR101053, LC110202, BC132124]
- Joanne and John DallePezze Foundation
- Derfner Foundation
- Commonwealth Foundation for Cancer Research
- Experimental Therapeutics Center
Ask authors/readers for more resources
Immunotherapy is a promising field that harnesses the power of the immune system as a therapeutic agent for cancer treatment. Beneficial outcomes shown in patients with non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma (MPM) with relatively higher tumor-infiltrating T cells, combined with impressive responses obtained in a cohort of patients with NSCLC following checkpoint blockade therapy, lays a strong foundation to promote effector immune responses in these patients. One such approach being investigated is administration of tumor antigen-targeted T cells with transduction of a chimeric antigen receptor (CAR). CARs are synthetic receptors that enhance T-cell antitumor effector function and have gained momentum to investigate in solid tumors based on recent successes of clinical trials treating patients with B-cell hematologic malignancies. This review summarizes target antigens for CAR T-cell therapy that are being investigated in preclinical studies and clinical trials for both NSCLC and MPM patients. We discuss the rationale for combination immunotherapies for NSCLC and MPM patients. Additionally, we have highlighted the challenges and strategies for overcoming the obstacles facing translation of CAR T-cell therapy to solid tumors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available