Journal
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
Volume 11, Issue -, Pages S841-S851Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dsx.2017.07.004
Keywords
Asymmetric dimethylarginine; Endothelial dysfunction; Insulin resistance; Oxidative stress; Sirtuin-1
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Polycystic ovarian syndrome (PCOS) is associated with multiple cardiovascular risk factors (CVRF) including endothelial dysfunction (ED) and presence of metabolic syndrome (MS). The probable reason suggested for elevated CVRF in PCOS is oxidative stress (OS), which is an integral factor in cardiometabolic complications (CMC) seen in PCOS women. The interrelated mechanisms by which CVRF instigate clinical manifestation plays a crucial role in identification of a strategy to treat different comorbidities in PCOS. The existing treatment for PCOS mostly focuses on management of individual disorders, however, therapeutic strategies or novel targets to address cardiovascular complications in PCOS deserve extensive analysis. (C) 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.
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