Journal
BIOMARKERS IN MEDICINE
Volume 11, Issue 11, Pages 1017-1029Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2017-0141
Keywords
biomarkers; metabolomics; treatment; tuberculosis
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Funding
- National Research Foundation (NRF) of South Africa [95269, 94217]
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Despite the fact that tuberculosis (TB) is a curable disease, it still results in approximately 1.8 million deaths annually. Various inadequacies in the current TB treatment strategies are major contributors to this high disease prevalence, including the long duration of therapy, the severe side effects associated with TB drugs, treatment failure due to drug resistance, post-treatment disease relapse, and HIV co-infection. In this review, we describe how metabolomics has contributed toward better explaining/elucidating the mechanisms of drug action/metabolism, drug toxicity and microbial drug resistance, and how metabolite biomarkers may serve as prognostic indicators for predicting treatment outcome as well as for the development of new TB drugs. We also discuss possible future contributions that metabolomics can make toward more efficient, less toxic TB treatment strategies.
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