Journal
ANNALS OF HUMAN BIOLOGY
Volume 44, Issue 6, Pages 489-494Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03014460.2017.1327617
Keywords
Adipokine; body mass index; waist circumference; a body shape index; insulin resistance; glucose; adolescent; obesity
Funding
- Sao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP) [2011/22768-2, 2012/11061-8]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [11/22768-2, 12/11061-8] Funding Source: FAPESP
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Background: Besides body mass index (BMI), new parameters have been developed to classify individual body shape. Aim: To investigate the relationship between BMI, waist circumference (WC), a body shape index (ABSI) and ABSI-adolescents among adolescents and verify which would better predict lower adiponectin/ leptin (A/L) ratio and disturbances on glucose metabolism. Subjects and methods: A cross-sectional study with 197 Brazilian adolescents of 14-18 years. Serum leptin, adiponectin, glucose and insulin were measured. A/L ratio, ABSI, ABSI-adolescents, BMI, homeostasis model assessment estimates of insulin resistance (HOMA-IR) and beta-cell function (HOMA-b) and the quantitative insulin sensitivity check index (QUICKI) were calculated. Results: ABSI-adolescents positively correlated with WC (r = 0.83, p < 0.0001) and BMI (r = 0.66, p< 0.0001), but stronger correlations were observed between WC and BMI (r = 0.95, p < 0.0001). ABSIadolescents, BMI and WC negatively correlated with A/L ratio (all p < 0.0001). The correlation between BMI and A/L ratio was the strongest (r = -0.63, p < 0.001). A/L ratio, BMI, WC and ABSI-adolescents correlated with markers of glucose metabolism (all p < 0.0001) and the strongest correlation was observed with BMI (QUICKI: r = -0.75; HOMA-IR: r = 0.76; HOMA-beta: r = 0.77; insulin: r = 0.79). Associations were confirmed by linear regression analysis, adjusted for sex and age. Conclusions: ABSI-adolescents, but not ABSI, was related to A/L ratio and to markers of glucose metabolism, but not more strongly than BMI and WC.
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