Journal
ANAIS BRASILEIROS DE DERMATOLOGIA
Volume 92, Issue 5, Pages 667-673Publisher
ELSEVIER SCIENCE INC
DOI: 10.1590/abd1806-4841.20175603
Keywords
Biological factors; Biological therapy; Biological treatment; Clinical trials as topic; Psoriasis; Therapies, investigational
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Biological therapy has revolutionized moderate to severe psoriasis treatment. However, despite being more effective than conventional systemic treatments, some patients do not respond or lose response to biotechnological treatments or develop drug-antibodies, interfering with its safety and efficacy. There are also clinical forms of the disease and patient profiles for which is pending further scientific evidence for more sustained therapeutic interventions. The continuous and more detailed knowledge of psoriasis pathophysiology has allowed identifying new therapeutic targets, which is expected to help overcome the challenges of individualized psoriasis treatment.
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