Journal
IRANIAN JOURNAL OF CHEMISTRY & CHEMICAL ENGINEERING-INTERNATIONAL ENGLISH EDITION
Volume 36, Issue 3, Pages 1-13Publisher
JIHAD DANESHGAHI
Keywords
N-propargylamines; Morpholines; 6-exo-dig cyclization; Cyclo-ketalization; Bridged systems
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Functionalized morpholines have attracted much attention due to their potential biological activities. Despite wide importance of morpholine derivatives in drug design of various pharmacological agents, the development of new approaches to their synthesis remains relatively unexplored. Given the low cost and easy availability of N-propargylamines, the synthesis of functionalized morpholines from these versatile building blocks have undergone an explosive growth in recent years. This review provides concise overview on the synthesis of morpholine cores from N-propargyalamines in recent years.
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