Journal
2017 IEEE 14TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2017)
Volume -, Issue -, Pages 1092-1095Publisher
IEEE
Keywords
Global tracking; Hybrid model selection; Endocytosis; Clathrin; Fitting; Mixture model
Categories
Funding
- Fondation pour la Recherche Medicale
- Philippe Foundation
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In this work we set several mathematical tools to study the role of Dynamin and Endophilin in the Clathrin-mediated endocytosis process. Their different dynamics and co-localizations are observed by using TIRF microscopy. We define in particular a novel tracking method in order to track the Clathrin-coated pits and quantify their co-localization with the proteins involved in the process. Thereafter, we perform a statistical analysis of the lifetimes of Clathrin-coated pits tracks by a suitable mixture model. This allows to define different populations of interest and point out the role of Endophilin and Dynamin in the process.
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