Journal
CANCER JOURNAL
Volume 23, Issue 6, Pages 315-320Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PPO.0000000000000286
Keywords
Cancer; pancreatic cancer; pancreatic ductal adenocarcinoma (PDA); PDA biology; PDA genetics
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Funding
- National Institutes of Health, NCI [CA0109029, P0513423, CA178015]
- US Department of Defense [W81XWH-16-1-0471]
- Hope Funds for Cancer Research
- Doris Duke Charitable Foundation
- Dana-Farber Cancer Institute Hale Center for Pancreatic Cancer [P50CA127003]
- Harvard Clinical and Translational Science Center [UL1 TR001102]
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Pancreatic ductal adenocarcinoma (PDA) remains one of the most devastating diagnoses in modern medicine. While the clinical management of the disease has improved, the complex biologic underpinnings of PDA enable both its aggressive nature and slow clinical translational progress. In this review, we provide an overview of the key features of PDA genetics and biology, highlighting translational challenges and providing a framework for improved diagnostic and therapeutic approaches.
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