Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 89, Issue -, Pages 190-196Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2017.02.007
Keywords
FTIR microscopy; QCL-IR imaging; 3D chemical imaging; Digital pathology; Clinical routine
Categories
Funding
- Ligue Nationale contre le cancer
- Agence Nationale de la Recherche (ANR) [2013-001-3DXIR-Pathology]
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IR microscopy was first conceptualized in 1949 and the first commercial system was launched 1983. With the appearance of FPA detectors in the 90's, FTIR microscopy became a technique of choice for histology. Two decades later, the release of QCLs working in the mid-IR range refuels this promise by accelerating tremendously the acquisition of IR images for large tissue areas with high-quality spectra for chemical mapping of parameters of interest. The new QCL-IR imaging system allows a 150x faster spectral data acquisition at equivalent S/N level. The quality of spectral data is comparable while applying spectral curve-fitting treatments, thus showing that laser sources offer reliable signal over a large spectral range. If QCL-IR imaging system seem to offer the opportunity to develop routines for anatomo-pathology, several technological challenges stand in front of us to reach this goal to define the specs of an IR microscope dedicated to hospital. (C) 2017 Elsevier B.V. All rights reserved.
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