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Current challenges and future prospects in chromatographic method development for pharmaceutical research

Journal

TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 95, Issue -, Pages 36-46

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2017.07.021

Keywords

Liquid chromatography; Supercritical fluid chromatography; Method development workflow; Method screening; Analytical method modeling; Quality-by-design; Allotrope Foundation; Pharmaceutical analysis

Funding

  1. MRL Postdoctoral Research Fellows program

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A survey of different strategies for chromatographic method development in pharmaceutical research and development is presented. Owing to the widespread utilization of chromatography within diverse areas of pharmaceutical research, a variety of strategies for method development have arisen. We survey the current state of the art, discuss recent trends and approaches and highlight future prospects and capability gaps. (C) 2017 Elsevier B.V. All rights reserved.

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