Journal
TOXIN REVIEWS
Volume 37, Issue 2, Pages 123-127Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15569543.2017.1329211
Keywords
Gastroprotection; amifostine; T-2 toxin; acute; gastric lesions; rats
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Funding
- Ministry of Education, Science and Technological Development of the Republic of Serbia
- Ministry of Defense of the Republic of Serbia
- long-term development plan UHK
- UHHK of the Czech Republic
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Cytoprotector amifostine (AMI) was given in a dose of 50, 100 or 150mg/kg ip in rats treated with several highly toxic doses of T-2 toxin. The best survival rate (24h and 7days after treatment) was obtained with AMI50 (50mg/kg ip). After T-2 intoxication, a peak in the mean number of gastric lesions (petechiae and ulcerations) was reached on the third day (26.40 +/- 6.24). Administration of AMI50 reduced, almost completely, the total number of gastric lesions in rats acutely poisoned by 0.5 LD50 T-2 (1.5mg/kg sc), starting with day 1 after intoxication (5.60 +/- 3.42).
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