Journal
TOXIN REVIEWS
Volume 37, Issue 3, Pages 223-230Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15569543.2017.1354305
Keywords
Lead; rutin; antioxidant enzymes; hepatotoxicity
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The present study was designed to evaluate the effect of rutin (RT) on lead (Pb)-induced oxidative stress. Rats were divided into groups and were treated with RT with or without lead. Levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and interleukin-1 (IL-1) were evaluated. Levels of AST, ALT, TNF-, IL-6, and IL-1 were significantly decreased, and the activities of antioxidant enzymes were increased in the liver of rats treated with RT along with Pb. Histologic changes were improved to almost a normal hepatic structure. The results suggest that RT controls the damaged antioxidant status in Pb-induced oxidative stress.
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