Effect of rutin on proinflammatory cytokines and oxidative stress in toxin-mediated hepatotoxicity

The present study was designed to evaluate the effect of rutin (RT) on lead (Pb)-induced oxidative stress. Rats were divided into groups and were treated with RT with or without lead. Levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and interleukin-1 (IL-1) were evaluated. Levels of AST, ALT, TNF-, IL-6, and IL-1 were significantly decreased, and the activities of antioxidant enzymes were increased in the liver of rats treated with RT along with Pb. Histologic changes were improved to almost a normal hepatic structure. The results suggest that RT controls the damaged antioxidant status in Pb-induced oxidative stress.