Journal
BIOTECHNOLOGY FOR BIOFUELS
Volume 10, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13068-017-0992-9
Keywords
Diols; Bioresource; Pathway design; New metabolic pathway; Metabolic engineering
Funding
- National Natural Science Foundation of China [21406131, 21676156]
- Suzhou-Tsinghua Innovation leading Project [20171470060]
- Tsinghua University's Initiative Scientific Research Program [20151080362]
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C2-C4 diols classically derived from fossil resource are very important bulk chemicals which have been used in a wide range of areas, including solvents, fuels, polymers, cosmetics, and pharmaceuticals. Production of C2-C4 diols from renewable resources has received significant interest in consideration of the reducing fossil resource and the increasing environmental issues. While bioproduction of certain diols like 1,3-propanediol has been commercialized in recent years, biosynthesis of many other important C2-C4 diol isomers is highly challenging due to the lack of natural synthesis pathways. Recent advances in synthetic biology have enabled the de novo design of completely new pathways to non-natural molecules from renewable feedstocks. In this study, we review recent advances in bioproduction of C2-C4 diols, focusing on new metabolic pathways and metabolic engineering strategies being developed. We also discuss the challenges and future trends toward the development of economically competitive processes for bio-based diol production.
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