Impact of pesticides mixtures

Pesticides are well thought out as risk factors for human health. The impact on consumers' health who are exposed to low doses mixtures, is still poorly defined. Pesticides are biologically active compounds having effects on various cellula targets and their combinations lead to a broad spectrum of responses: addition, synergy, antagonism and potentiation. When combined, pesticides can interact at different levels on specific targets linked to their chemical class (mechanism of toxicity) and/or on toxicokinetic level. In addition, the cocktail effect can be derived from an interaction network involving different cellular targets. The bases of the interaction between pesticides compounds are complex and the question still remains as to the notion of toxicity mechanisms (additive, synergistic etc) are well adapted to talk about the multiple interaction levels networks. (C) 2017 Societe francaise de nutrition. Published by Elsevier Masson SAS. All rights reserved.