Journal
NEPHRON
Volume 137, Issue 4, Pages 282-286Publisher
KARGER
DOI: 10.1159/000477181
Keywords
Acute kidney injury; Immune cells; Inflammation; Kidney repair; Neutrophil; Macrophage; Dendritic cells; T lymphocyte; B lymphocyte; Double-negative T cells; Regulatory T cells
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Funding
- National Institutes of Health [R01-DK111209, R01-DK104662]
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Acute kidney injury (AKI) is a significant problem in both native and transplant kidneys. There have been significant advances in understanding the role of immune cells in the early injury and repair from AKI. In this brief review, we aim to update information on the pathophysiologic impact of various immune cells in AKI, with special emphasis on repair. An improved understanding of the AKI immunopathology will lead to new therapies that prevent AKI, accelerate repair, and prevent the progression of AKI to chronic kidney disease. (C) 2017 S. Karger AG, Basel
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