Journal
CELL
Volume 171, Issue 7, Pages 1663-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2017.11.002
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Funding
- Pew
- McKnight
- Sloan Foundation
- NIH [DP2 DA035149-01, 5R01MH106689-02, 1F32MH112320-01A1]
- SCGB [412733]
- NSF GRFP
- NARSAD
- NCATS NIH CTSA [UL1 TR001866]
- McKnight Foundation
- Simons Collaboration on the Global Brain [SCGB AWD1004351]
- NSF CAREER Award [IIS-1150186]
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Social behaviors are crucial to all mammals. Although the prelimbic cortex (PL, part of medial prefrontal cortex) has been implicated in social behavior, it is not clear which neurons are relevant or how they contribute. We found that PL contains anatomically and molecularly distinct subpopulations that target three downstream regions that have been implicated in social behavior: the nucleus accumbens (NAc), amygdala, and ventral tegmental area. Activation of NAc-projecting PL neurons (PL-NAc), but not the other subpopulations, decreased the preference for a social target. To determine what information PL-NAc neurons convey, we selectively recorded from them and found that individual neurons were active during social investigation, but only in specific spatial locations. Spatially specific manipulation of these neurons bidirectionally regulated the formation of a social-spatial association. Thus, the unexpected combination of social and spatial information within the PL-NAc may contribute to social behavior by supporting social-spatial learning.
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