Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 96, Pages 12930-12933Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc07699a
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Funding
- JST/CREST [JPMJCR14W3]
- JSPS KAKENHI [16H03281]
- Grants-in-Aid for Scientific Research [16H03281] Funding Source: KAKEN
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We found that Escherichia coli MazF toxin, an ACA-sequence-specific endoribonuclease, was sensitive to N-6-methyladenosine (m6A), representing the first m6A-sensitive RNA cleavage enzyme. The methyl-sensitivity of MazF allowed simple analyses of both m6A demethylase and methyltransferase activity. Furthermore, the approach could be used for inhibitor screening.
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