Journal
FLUIDS AND BARRIERS OF THE CNS
Volume 14, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12987-017-0080-3
Keywords
Opioids; Morphine; Pain; Blood-brain barrier; P-Glycoprotein; Opioid tolerance
Categories
Funding
- NIH [5 R01 DA011271, 5 R01 NS042652]
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Opioids are currently the primary treatment method used to manage both acute and chronic pain. In the past two to three decades, there has been a surge in the use, abuse and misuse of opioids. The mechanism by which opioids relieve pain and induce euphoria is dependent on the drug crossing the blood-brain barrier and accessing the central nervous system. This suggests the blood brain barrier plays a central role in both the benefits and risks of opioid use. The complex physiological responses to opioids that provide the benefits and drive the abuse also needs to be considered in the resolution of the opioid epidemic.
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