Journal
BIOINFORMATICS
Volume 33, Issue 24, Pages 3982-3984Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btx513
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Funding
- Royal Society
- Chinese Academy of Sciences [164914]
- Chinese Scholarship Council (CSC)
- MRC [MR/M025411/1]
- UCLH/UCL Comprehensive Biomedical Research Centre
- National Institute for Health Research (NIHR) Blood & Transplant Research Unit (BTRU) [NIHR-BTRU-2014-10074]
- MRC [MR/M025411/1] Funding Source: UKRI
- Gynaecology Research Fund (The Eve Appeal) [537067] Funding Source: researchfish
- Medical Research Council [MR/M025411/1] Funding Source: researchfish
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The Illumina Infinium HumanMethylationEPIC BeadChip is the new platform for high-throughput DNA methylation analysis, effectively doubling the coverage compared to the older 450 K array. Here we present a significantly updated and improved version of the Bioconductor package ChAMP, which can be used to analyze EPIC and 450k data. Many enhanced functionalities have been added, including correction for cell-type heterogeneity, network analysis and a series of interactive graphical user interfaces.
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