Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 96, Pages 12890-12893Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc08018b
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Funding
- European Research Council
- EPSRC [EP/K039547/1]
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We have discovered that the dba ligand in the commonly used Pd-2(dba)(3)center dot CHCl3 cross-coupling pre-catalyst is susceptible to bis-arylation when used in the presence of aryl iodides. The in situ formed dbaAr(2) ligands result in Pd-species with altered catalytic activity. In the case of study, the room temperature C3 arylation of benzo[b] thiophenes with aryl iodides, we have observed a marked catalyst deactivation when dba is arylated with electron-deficient aryl iodides, accounting for the poor yields obtained in the C3 arylation reactions with these aryl iodides. Based on these studies, we report a new catalytic system, employing a dba-free Pd catalyst, which allows for the first time the direct C3 arylation of benzo[b]-thiophenes with electron-deficient aryl iodides at room temperature.
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