Journal
ACTA OPHTHALMOLOGICA
Volume 95, Issue 8, Pages e751-e755Publisher
WILEY
DOI: 10.1111/aos.13404
Keywords
deep capillary plexus; diabetic retinopathy; optical coherence tomography angiography; type 1 diabetes
Categories
Funding
- Italian Ministry of Health
- Fondazione Roma
Ask authors/readers for more resources
PurposeDiabetic retinopathy (DR) can lead to significant vision loss and blindness and has a particularly high prevalence in patients with type 1 diabetes (DM1). In this study, we investigate quantitative differences in optical coherence tomography angiography (OCTA) data between DM1 patients with no or mild signs of retinopathy and non-diabetic subjects. MethodsOptical coherence tomography angiography (OCTA) imaging was performed on DM1 patients with no or mild nonproliferative diabetic retinopathy and healthy, age-matched controls. Parafoveal vessel density and foveal avascular zone (FAZ) area in the deep capillary plexus (DCP) and superficial capillary plexus (SCP) were calculated with automated quantification software and compared between patient cohorts. ResultsA significant decrease in parafoveal vessel density was seen in the DCP of DM1 patients compared to non-diabetic controls (57.03.3% versus 60.7 +/- 2.4%, p<0.001). There was no significant difference in SCP parafoveal vessel density, DCP FAZ area, or SCP FAZ area between cohorts. ConclusionM1 patients with no or mild signs of retinopathy have reduced parafoveal vessel density in the DCP on OCTA when compared to non-diabetic controls. These OCTA findings suggest that parafoveal capillary nonperfusion is an early process in DM1-related retinal changes and occurs initially at the level of the DCP. Further investigation is needed to understand the prognostic role of these vascular changes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available