Journal
TISSUE ENGINEERING PART C-METHODS
Volume 23, Issue 3, Pages 146-155Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.tec.2016.0492
Keywords
cardiac patch; platelet fibrin gel; myocardial infarction; regeneration
Categories
Funding
- National Institute of Health [HL123920]
- NC State University Chancellor's Faculty Excellence Program
- NC State Chancellor's Innovation Fund
- University of North Carolina General Assembly Research Opportunities Initiative grant
- National Natural Science Foundation of China [81370216, 81570274]
- Science and Technology Innovation Team Support Project of Henan Province [14IRTSTHN018]
- Innovation Team of Science and Technology Project of Henan Province
- China Scholarship Council
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Layering a regenerative polymer scaffold on the surface of the heart, termed as a cardiac patch, has been proven to be effective in preserving cardiac function after myocardial infarction (MI). However, the placement of such a patch on the heart usually needs open-chest surgery, which is traumatic, therefore prevents the translation of this strategy into the clinic. We sought to device a way to apply a cardiac patch by spray painting in situ polymerizable biomaterials onto the heart with a minimally invasive procedure. To prove the concept, we used platelet fibrin gel as the paint'' material in a mouse model of MI. The use of the spraying system allowed for placement of a uniform cardiac patch on the heart in a mini-invasive manner without the need for sutures or glue. The spray treatment promoted cardiac repair and attenuated cardiac dysfunction after MI.
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