Journal
FUTURE SCIENCE OA
Volume 3, Issue 3, Pages -Publisher
FUTURE SCI LTD
DOI: 10.4155/fsoa-2016-0095
Keywords
HSC; Notch; SCID; thymus; T lymphocyte; Wnt
Categories
Funding
- KIKA (Children Cancer Free) [36]
- ZonMW E-RARE [40-41900-98-020]
- EU H grant SCID-NET
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T cells develop from hematopoietic stem cells in the specialized microenvironment of the thymus. The main transcriptional players of T-cell differentiation such as Notch, Tcf-1, Gata3 and Bcl11b have been identified, but their role and regulation are not yet completely understood. In humans, functional experiments on T-cell development have traditionally been rather difficult to perform, but novel in vitro culture systems and in vivo xenograft models have allowed detailed studies on human T-cell development. Recent work has allowed the use of human severe combined immunodeficiency stem cells to unravel developmental checkpoints for human thymocyte development.
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