Journal
THROMBOSIS AND HAEMOSTASIS
Volume 117, Issue 8, Pages 1622-1629Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH17-02-0076
Keywords
Pulmonary embolism; computed tomography; diagnosis; safety
Categories
Funding
- Netherlands Heart Foundation [2006B224]
- Swiss National Research Foundation [32003B-130863]
- International Society on Thrombosis and Haemostasis, from the Dutch Thrombosis Foundation [2010-5]
- Projets Hospitaliers de Recherche Clinique, French Ministry of Health [PHRC 2011 08-01]
- Direction de la Recherche Clinique et de l'Innovation, Brest University Hospital
- Center of Clinical Research, Geneva University Hospital
- Swiss National Science Foundation (SNF) [32003B_130863] Funding Source: Swiss National Science Foundation (SNF)
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A normal computed tomography pulmonary angiography (CTPA) remains a controversial criterion for ruling out acute pulmonary embolism (PE) in patients with a likely clinical probability. We set out to determine the risk of VTE and fatal PE after a normal CTPA in this patient category and compare these risk to those after a normal pulmonary angiogram of 1.7% (95 %CI 1.0-2.7%) and 0.3 % (95 %CI 0.02-0.7 %). A patient-level meta-analysis from 4 prospective diagnostic management studies that sequentially applied the Wells rule, D-dimer tests and CTPA to consecutive patients with clinically suspected acute PE. The primary outcome was the 3-month VTE incidence after a normal CTPA. A total of 6,148 patients were included with an overall PE prevalence of 24 %. The 3-month VTE incidence in all 4,421 patients in whom PE was excluded at baseline was 1.2 % (95 %CI 0.48-2.6) and the risk of fatal PE was 0.11 % (95 %CI 0.02-0.70). In patients with a likely clinical probability the 3-month incidences of VTE and fatal PE were 2.0% (95 %CI 1.0-4.1 %) and 0.48% (95 %CI 0.20-1.1 %) after a normal CTPA. The 3-month incidence of VTE was 6.3% (95 %CI 3.0-12) in patients with a Wells rule >6 points. In conclusion, this study suggests that a normal CTPA may be considered as a valid diagnostic criterion to rule out PE in the majority of patients with a likely clinical probability, although the risk of VTE is higher in subgroups such as patients with a Wells rule >6 points for which a closer follow-up should be considered.
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