Journal
BMC BIOLOGY
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12915-017-0464-5
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Funding
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/N007603/1]
- European Research Council under the European Union's Seventh Framework Programme [322408]
- BBSRC [BB/N007603/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/N007603/1] Funding Source: researchfish
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The cell envelope is essential for the survival of Gram-negative bacteria. This specialised membrane is densely packed with outer membrane proteins (OMPs), which perform a variety of functions. How OMPs fold into this crowded environment remains an open question. Here, we review current knowledge about OMP folding mechanisms in vitro and discuss how the need to fold to a stable native state has shaped their folding energy landscapes. We also highlight the role of chaperones and the beta-barrel assembly machinery (BAM) in assisting OMP folding in vivo and discuss proposed mechanisms by which this fascinating machinery may catalyse OMP folding.
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