Journal
DALTON TRANSACTIONS
Volume 46, Issue 47, Pages 16446-16454Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7dt03242k
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Funding
- Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University [GK2014-TKF05]
- Guangxi Natural Science Foundation [2016GXNSFAA380292]
- National Natural Science Foundation of China [21661011]
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The single crystals of two novel mixed-ligand copper(II)-based complexes were obtained and characterized. These complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis to inhibit the growth of cervical cancer by down-regulating the expressions of the important proteins FAK, Akt and Erk1/2 or their phosphorylated proteins p-FAK, p-Akt, and p-Erk1/2 downstream of the VEGF/VEGFR2 signaling pathway.
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