Journal
THORAX
Volume 73, Issue 3, Pages 286-289Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2016-209313
Keywords
viral infection; respiratory infection; infection control
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Funding
- Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI15C2774, HI15C2859, HI15C2888]
- National Research Foundation - Ministry of Science, ICT and Future Planning, Republic of Korea [NRF-2015R1A4A1042416]
- Asan Institute for Life Sciences [2016-462]
- Korean Society for Chemotherapy
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We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.
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