Journal
THORAX
Volume 73, Issue 5, Pages 486-488Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2017-210842
Keywords
-
Categories
Funding
- National Heart, Lung, and Blood Institute [N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169]
- NCRR [UL1-TR-000040, UL1-RR-025005]
- US Environmental Protection Agency [RD831697]
- [R01-HL077612]
- [R01-HL093081]
- [RC1-HL100543]
- [K23-HL-130627]
- [R21-HL129924]
- [R01-HL130506]
Ask authors/readers for more resources
Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. We used data from 2045 adult participants without initial prebronchodilator airflow limitation, classified by FEV1/FVC<0.70, in the Multi-Ethnic Study of Atherosclerosis. Emphysema-like lung on baseline cardiac CT, defined as per cent low attenuation areas(<-950HU) > upper limit of normal, was associated with increased odds of incident airflow limitation at 5-year follow-up on both prebronchodilator (adjusted OR 2.62, 95% CI 1.47 to 4.67) and postbronchodilator (adjusted OR 4.38, 95% CI 1.63 to 11.74) spirometry, independent of smoking history. These results support investigation into whether emphysema-like lung could be informative for COPD risk stratification.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available