Journal
CHEMISTRY OF MATERIALS
Volume 29, Issue 24, Pages 10398-10408Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.7b03811
Keywords
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Funding
- Key Research and Development Program of Zhejiang province [2017C03005]
- SJTU-JOINSTAR Joint Lab Innovation Project
- SJTU funding [YG2015ZD11]
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Novel 3D barcodes with an extraordinarily high encoding capacity are developed through a flexible, accurate, and reproducible method. Here, the three dimensions refer to the size, fluorescence emission wavelength, and intensity of the barcodes. As a proof of concept, a 3D barcode library with an encoding capacity of 100 flow cytometry-distinguishable barcodes is achieved successfully by combining the multiscaled host particles with a set of guest nanoparticles owning to their individual different fluorescent intensity via an ingenious host guest structure, where fluorescein isothiocyanate and a kind of quantum dots are separately loaded inside. Five-plexed tumor marker detection is further implemented, and the results demonstrate the strong feasibility of 3D barcodes in multiplex assays.
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