Journal
BMC BIOLOGY
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12915-017-0454-7
Keywords
Microbiome; Evolution; Codiversification; Habitat filtering; Transmission
Categories
Funding
- NIH [F32 DK109595]
- Keck Foundation
- Templeton Foundation
- Howard Hughes Medical Institute (Earth Microbiome Project)
- NSF
- NIH
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The trillions of microbes living in the gut-the gut microbiota-play an important role in human biology and disease. While much has been done to explore its diversity, a full understanding of our microbiomes demands an evolutionary perspective. In this review, we compare microbiomes from human populations, placing them in the context of microbes from humanity's near and distant animal relatives. We discuss potential mechanisms to generate host-specific microbiome configurations and the consequences of disrupting those configurations. Finally, we propose that this broader phylogenetic perspective is useful for understanding the mechanisms underlying human-microbiome interactions.
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