Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 94, Issue -, Pages 292-306Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2017.07.064
Keywords
Gallesia integrifolia; Essential oil; Gastric ulcer; Toxicity; Phytochemical analysis
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq/BIONORTE) [551737/2010-7]
- National Post-Doctoral Fellowship (CAPES/PNPD) [23108.180072/2016-02]
- Fundacao de Amparo a Pesquisa do Estado de Mato Grosso (FAPEMAT) [205978/2011]
- Instituto Nacional de Ciencia e Tecnologia em Areas Umidas (INAU)/CNPq/MCTI [704792/2009]
Ask authors/readers for more resources
Gallesia integrifolia is a Brazilian Amazon tree whose bark decoction is popularly used to treat peptic ulcer. The essential oil from the inner stem bark of G. integrifolia (EOGi) was chemically characterized by GC/MS. The in vitro cytotoxicity and genotoxicity were evaluated in CHO-K1 cells, while the in vivo oral acute toxicity was performed in mice. The gastroprotective effect of EOGi was assessed in acidified ethanol and piroxicam and ulcer healing on acetic acid-induced ulcer models in rodents. Anti-secretory, mucus, K+-ATP channels, prostaglandins (PGs), nitric oxide (NO), TNF-alpha, IL-1 beta, IL-10, catalase (CAT) and myeloperoxidase (MPO) activities and in vitro Helicobacter pylori action by EOGi were evaluated. EOGi exhibited cytotoxic effects only at 72 h and no acute toxicity. EOGi showed gastroprotective and ulcer healing effects. EOGi gastroprotection was attenuated by indomethacin pre-treatment. Gastric volume and total acidity were reduced, while gastric pH was elevated. EOGi increased mucus and NO productions and CAT activity, and inhibited MPO activity, TNF-alpha and IL-1 beta concentrations and augmented IL-10. EOGi was not active against H. pylori. These results indicated that EOGi is safe and exerts preventive and curative gastric ulcer effects by multitarget actions. Twenty compounds were identified and (-)-alpha-santalene was the main compound. (C) 2017 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available