Journal
GENES & DISEASES
Volume 4, Issue 1, Pages 19-24Publisher
ELSEVIER
DOI: 10.1016/j.gendis.2016.11.003
Keywords
Angiogenesis; HIF; Hypoxia; Metabolism; VHL
Funding
- National Nature Science Foundation of China [81272960]
- Key Research Program from Science and Technology Department of Hunan Province, China [2013WK2010, 2014SK2015]
- Ministry of human Resources and Social Security of the People's Republic of China [176]
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Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular metabolism. In this review, we focused on the pivotal role of HIF in tumor angiogenesis and energy metabolism. Furthermore, we also emphasized the possibility of HIF pathway as a potential therapeutic target in cancer. Copyright (C) 2016, Chongqing Medical University. Production and hosting by Elsevier B.V.
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