Journal
SMALL METHODS
Volume 1, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smtd.201700304
Keywords
drug delivery; erythrocytes; nanomedicine; nanoparticles; red blood cells
Funding
- Alfred P. Sloan Foundation
- American Diabetes Association (ADA) [1-15-ACE-21]
- JDRF [2-SRA-2016-269-A-N]
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Red blood cells (RBCs), or erythrocytes, have been promising endogenous candidates for drug delivery for more than four decades. Armed with a better understanding of the diverse mechanisms and paths for drug delivery, researchers have achieved great progress in manufacturing RBC-based carriers, from both the scientific and clinical viewpoints. Here, the loading methods and loading therapeutics by RBC carriers are surveyed, and recent advances in the design of stimuli-triggered RBC carriers highlighted. Key developing trends and challenges, are also discussed, and an outlook is presented.
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