Journal
ANALYTICAL CHEMISTRY
Volume 89, Issue 23, Pages 13016-13023Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.7b04142
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21475048]
- National Science Fund for Distinguished Young Scholars of Guangdong Province [2014A030306008]
- Project of Guangzhou Science and Technology Plan [201508020003]
- Program of the Pearl River Young Talents of Science and Technology in Guangzhou [2013J2200021]
- Special Support Program of Guangdong Province [2014TQ01R599]
- Outstanding Young Teacher Training Program of Guangdong Province [HS2015004]
Ask authors/readers for more resources
Electrochemiluminescence (ECL) has been engineered to perform various tasks in the area of immunoassays and molecular diagnosis. However, there is still substantial potential for developments of ECL assay with high efficiency to achieve trace analysis. Herein, we demonstrate a polymer amplified ECL assay via construction of linear Ru(bpy)(3)(2+) polymer. This new polymer material compensates for the relatively low ECL intensity from single ECL luminophore and realizes a stable and controllable labeling process. The polymer amplified ECL assay achieved a remarkable sensitivity of 100 amol. The wide-ranging applications of the polymer-amplified ECL assay for Hepatitis B virus, carcinoembryonic antigen, 16sRNA, and thrombin also demonstrate its superiority. Hence, the polymer-amplified ECL assay possesses the potential to create a new paradigm in amplified ECL assays that could provide outstanding performance for biomedical analysis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
