Journal
ANALYTICAL CHEMISTRY
Volume 89, Issue 23, Pages 12984-12991Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.7b04033
Keywords
-
Categories
Funding
- Guangxi Natural Science Foundation [2016GXNSFBA380229]
- BAGUI Scholar program of Guangxi Province of China
- Graduate Innovation Training Program of Guangxi Province [YCSW2017189]
Ask authors/readers for more resources
Glutathione (GSH) and hydrogen polysulfides (H2Sn) play crucial roles in many physiological processes. To unravel the complicated interrelationship and cellular cross-talk between GSH and H2Sn, the development of single molecule fluorescent probes that can selectively sense GSH and H2Sn simultaneously from different emission channels is highly desirable. In this report, we have developed the first dual-detection fluorescent probe, ACC-SePh, which responded to GSH with green fluorescence emission, whereas it reacted with H2Sn and emitted blue fluorescence. The probe exhibited excellent selectivity and sensitivity toward GSH and H2Sn over other common reactive sulfur species, such as Cys, Hcy and H2S. Importantly, we also demonstrated that ACC-SePh can be used for dual-channel imaging of endogenous GSH and H2Sn in living RAW264.7 cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available