Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 48, Pages 41634-41640Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b14717
Keywords
nanopore functionalization; solid-state nanopore; polymer brush; ionic conductance; nanopore transport; microfluidics; protein
Funding
- DEFI CNRS Instrumentation aux limites
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Electrical detection based on single nanopores is an efficient tool to detect biomolecules, particles and study their morphology. Nevertheless the surface of the solid-state membrane supporting the nanopore should be better controlled. Moreover, nanopore should be integrated within microfluidic architecture to facilitate control fluid exchanges. We built a reusable microfluidic system integrating a decorated membran, rendering the drain and refill of analytes and buffers easier. This process enhances strongly ionic conductance of the nanopore and its lifetime. We highlight the reliability of this device by detecting gold nanorods and spherical proteins.
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