Journal
ACADEMIC RADIOLOGY
Volume 24, Issue 12, Pages 1575-1581Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.acra.2017.06.016
Keywords
Luminal-type breast cancer; magnetic resonance imaging; intravoxel incoherent motion; dynamic contrast-enhanced MR imaging; Ki-67 labeling index
Funding
- Grants-in-Aid for Scientific Research [17K10394] Funding Source: KAKEN
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Rationale and Objectives: The study aimed to investigate whether intravoxel incoherent motion (IVIM) and dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) can differentiate luminal-B from luminal-A breast cancer Materials and Methods: Biexponential analyses of IVIM and DCE MRI were performed using a 3.0-T MRI scanner, involving 134 patients with 137 pathologically confirmed luminal-type invasive breast cancers. Luminal-type breast cancer was categorized as luminal-B breast cancer (LBBC, Ki-67 >= 14%) or luminal-A breast cancer (LABC, Ki-67 < 14%). Quantitative parameters from IVIM (pure diffusion coefficient [D], perfusion-related diffusion coefficient [D*], and fraction [f]) and DCE MRI (initial percentage of enhancement and signal enhancement ratio [SER]) were calculated. The apparent diffusion coefficient (ADC) was also calculated using monoexponential fitting. We correlated these data with the Ki-67 status. Results: The D and ADC values of LBBC were significantly lower than those of LABC (P = 0.028, P = 0.037). The SER of LBBC was significantly higher than that of LABC (P = 0.004). A univariate analysis showed that a significantly lower D (<0.847 x 10(-3) mm(2)/s), lower ADC (<0.960 x 10(-3) mm(2)/s), and higher SER (>1.071) values were associated with LBBC (all P values <0.01), compared to LABC. In a multivariate analysis, a higher SER (>1.071; odds ratio: 3.0099, 95% confidence interval: 1.4246-6.3593; P=0.003) value and a lower D (<0.847 x mm(2)/s; odds ratio: 2.6878, 95% confidence interval: 1.0445-6.9162; P = 0.040) value were significantly associated with LBBC, compared to LABC. Conclusion: The SER derived from DCE MRI and the D derived from IVIM are associated independently with the Ki-67 status in patients with luminal-type breast cancer.
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