Journal
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
Volume 30, Issue 4, Pages 320-326Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2017.09.004
Keywords
Allogeneic; Acute myeloid leukemia; AML; Elderly; HET; Hematopoietic cell transplant
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For younger patients with intermediate- or high-risk acute myeloid leukemia (AML) in first remission, allogeneic hematopoietic cell transplantation (HCT) offers the best chance of cure and therefore is the treatment of choice. The role of allogeneic HCT in the treatment of older patients is less well defined. In this review, four issues concerning the role of HCT in the treatment of older AML patients will be addressed: the frequency of allogeneic HCT in the older AML population in the US; the impact of age on the outcome of HCT; the comparative outcome of allogeneic HCT versus chemotherapy in older AML patients; and some of the barriers to the effective use of HCT in older AML patients. (C) 2017 Published by Elsevier Ltd.
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