The PMe3-catalyzed addition of enantiomerically pure (-)-MenthylO (Ph)P(O)H to electron-deficient alkenes: an efficient way for the preparation of P-stereogenic compounds

A variety of P-stereogenic organophosphorus compounds can be readily prepared by stereoretentive addition. The PMe3-catalyzed addition of optically active (-)MenthylO(Ph)P(O)H compounds to electron deficient alkenes occur stereospecifically, to produce the corresponding P-stereogenic adducts in high yields. By simply removing the volatiles under vacuum, spectroscopically pure products can be obtained. The present method provides a salt-free clean process for the preparation of P-chiral organophosphorus compounds. (C) 2016 Elsevier Ltd. All rights reserved,