Journal
TETRAHEDRON-ASYMMETRY
Volume 28, Issue 10, Pages 1212-1219Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2017.09.009
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General strategies by which NMR spectroscopy can be used to assign absolute configuration are discussed. These include the use of chiral derivatizing and chiral solvating agents. Areas that are well developed and areas of need in this field are described. The future potential of using aligning media such as chiral liquid crystals and odd-parity effects that may make it possible to determine absolute configuration without the need for an enantiomerically pure reagent are discussed. (C) 2017 Elsevier Ltd. All rights reserved.
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