Journal
TETRAHEDRON LETTERS
Volume 58, Issue 14, Pages 1387-1389Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.02.060
Keywords
Palladium; 6-endo cyclization; Enynoates; 2-Pyrones
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Funding
- Department of Science and Technology (DST), New Delhi, India [SB/FT/CS-012/2014]
- Council of Scientific Industrial Research (CSIR), New Delhi, India [02(0201)/14/EMR-II]
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An efficient one-pot protocol for the synthesis of multi-substituted 2-pyrone derivatives from internal alkynes and unactivated alkenes is reported. The methodology involves difunctionalization of internal alkynes by using Pd(II) as a catalyst alongwith X-Phos as ligand via 6-endo transesterification and subsequent alkenylation pathway. Notable features include simple and easily available starting materials, including a range of unactivated alkenes, reduced synthetic steps and mild reaction conditions with high efficiency. (C) 2017 Elsevier Ltd. All rights reserved.
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