Straightforward synthesis of novel substituted 1,3,4-thiadiazole derivatives in choline chloride-based deep eutectic solvent

A one-pot, three-component route for the synthesis of novel 1,3,4-thiadiazole derivatives using a ketene S,S-acetal, a carbonyl compound and thiocarbohydrazide is described. The main advantages of this approach are high yields, short reaction times, simple reaction conditions and a green reaction medium. The 1,3,4-thiadiazole core has been substituted with biologically active groups such as arylhydrazones, coumarin, isatin, Meldrum's acid and barbituric acid. Structures of the thiadiazoles were elucidated from spectroscopic data. (C) 2017 Published by Elsevier Ltd.