4.4 Article

Efficient synthesis of isoindoles using supercritical carbon dioxide

Journal

TETRAHEDRON LETTERS
Volume 58, Issue 13, Pages 1338-1342

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.02.055

Keywords

Isoindole; Supercritical carbon dioxide; Bicyclopyrrole; Retro Diels-Alder reaction

Funding

  1. Network Joint Research Center for Materials and Devices [20161186]
  2. JSPS KAKENHI [JP16K05892]
  3. Grants-in-Aid for Scientific Research [16K05892] Funding Source: KAKEN

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Bicyclopyrroles were efficiently converted to the corresponding isoindoles by a retro Diels-Alder reaction in supercritical carbon dioxide. By adding ethylene gas as an oxygen scavenger, the isoindole yield was further improved. (C) 2017 Elsevier Ltd. All rights reserved.

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